There’s a common theme in philanthropy known as the multiplier effect. It refers to how an initial philanthropic gift can spur a chain reaction — creating ripples of long-term change, attracting more funding or inspiring broader support. This ultimately yields an impact greater than the original gift alone could achieve. In this issue of Leading, we showcase the multiplier effect by highlighting a number of special gifts, beginning with a transformational commitment from The Duncan Fund to Houston Methodist’s largest department. The Houston Methodist Charles W. Duncan Jr. Department of Medicine, home to 14 diverse clinical programs, promises to usher in an era of precision medicine and proactive health. It’s a vision shared by the Duncan family and department chair Dr. Eleftherios Mylonakis — and an investment that will be amplified through generations of medical training and leadership, initiative building, and capacity expansion. Please see our Spotlight story for more details.