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TRANSLATIONAL RESEARCH
A Journey of a Thousand Steps

Helping Stroke Patients Along the Path to Recovery
“My focus is on the patient,” says Dr. Timea Hodics of the Houston Methodist Neurological Institute. “I want to help them have hope no matter their situation.” It is this mindset that drives Dr. Hodics’ new clinical trial for stroke recovery patients. When selecting candidates, she seeks out subjects who have the greatest need.
Dr. Hodics’ outlook is shared by Houston Methodist donors Tom and Sharon Wilkes Simmons, who have become familiar with her work during Tom’s stroke recovery journey. Together, they established the Thomas and Sharon Wilkes Simmons Neuro Recovery Fund and helped kickstart Dr. Hodics’ three-year study of an external vagus nerve stimulator. This device, which is worn near the left ear, has the potential to significantly improve the rate of recovery for stroke patients undergoing physical and occupational therapy.
Though an implanted vagus nerve stimulator is already available, not every stroke patient is a candidate. For Tom, the risk of a second stroke during a surgery to implant the device was too high to chance, and for people who endure rare and remarkably dangerous hemorrhagic strokes, like patient Brooke Schmitt, the Food and Drug Administration has yet to approve the implant.
A young mother of two, Schmitt was only 36 years old when she suffered a stroke in 2021. Four years later, she still struggles with partial paralysis, but she is dedicated to recovering her mobility. “My fight is not over. I’ve tried a few different clinical trials — I’m determined that I’m not going to let this stroke win.”
Proactive and persistent, Schmitt and her parents, Shirley and Ralph Alexander, actively seek out novel therapies that may help her. When they learned about Dr. Hodics’ upcoming study, they chose to make a generous gift to cover the entirety of the remaining cost of the trial. Now, with the first phase drawing to a close, Dr. Hodics is highly encouraged by the results. “Before, patients with this level of impairment were deemed ‘unresponsive to treatment,’ but this study demonstrates they are indeed responsive. They just need a longer-term, more detailed and somewhat different intervention,” she says.
Schmitt adds, “When Dr. Hodics looked at my before-and-after data, she was on cloud nine.” Still on the road to full recovery, Schmitt is undaunted, saying, “I’m going to put 110% into this because I want it so badly.”
THIS DEVICE HAS THE POTENTIAL TO SIGNIFICANTLY IMPROVE THE RATE OF RECOVERY FOR STROKE PATIENTS UNDERGOING PHYSICAL AND OCCUPATIONAL THERAPY
For the Simmons family, both funding and participating in Dr. Hodics’ clinical trial seemed an obvious choice as well. “There comes a time when you want to help — you want to give back. Sitting in the rehab waiting room, I wanted to help each person who was in there,” Sharon says.
Schmitt echoes this sentiment: “I’m grateful for the clinical trial and am hopeful we’re able to help others. In the end, there are so many people out there going through this same hardship.”
Dr. Hodics recognizes that recovery remains “a marathon, not a sprint.” However, thanks to her study, patients are able to travel the long road toward rehabilitation with renewed hope. Sharon concludes, “Even if it takes 20 years to get there, that’s fine because we’re one year closer to it than we were a year ago.”
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