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PHYSICIAN HIGHLIGHT

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JENNY C. CHANG, MBChirB, MD
Ernest Cockrell, Jr. Presidential Distinguished Chair President and CEO, Houston Methodist Academic Institute Executive Vice President and Chief Academic Officer Houston Methodist Professor of Medicine, Weill Cornell Medical College
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Q: Which Emerging Areas of Medical Research Most Excite You?

It’s truly a watershed moment for medicine. Just over 20 years ago, the human genome was sequenced. Now, we know how the actual genetic drivers impact many diseases, including cancer. We also have the capabilities and tools to translate those discoveries for direct patient care.
Take bioengineered therapeutics, for example. Today, we can edit genes and create monoclonal antibodies or even personalized vaccines. Consider a cellular therapy that originates in a Houston Methodist lab. We can manufacture it in the Ann Kimball & John W. Johnson Center for Cellular Therapeutics, resulting in clinical-grade therapies that are FDA-approved for use in patients. Next, we can deliver these therapies to the Cockrell Center for Advanced Therapeutics for early-phase clinical trials. This continuum allows us to transform basic discoveries into personally targeted drugs and deliver them into our patients — entirely within our own ecosystem.

Q: How Can We Best Address Pervasive Age-Related Diseases?

There are many encouraging therapies on the horizon that I believe will ultimately impact these diseases. Let’s talk about dementia. Understanding that this and other neurodegenerative diseases have a major immunologic component, we now have emerging therapies that cross the blood-brain barrier to modify disease trajectory. We also know that patient outcomes can be improved with early detection, whether through advanced imaging — like our state-of-the-art 7-Tesla MRI scanner — or with promising blood-based profiling biomarkers. And since we operate a cellular therapeutics center, we have the capacity to produce investigational therapies onsite. All with the goal of offering new hope and improving outcomes for people suffering from these debilitating illnesses.

Q: HOW HAVE EXPERTS AT HOUSTON METHODIST CHANGED THE WAY OTHERS APPROACH MEDICINE?

Houston Methodist has changed the practice of medicine in several ways, beginning with its historic leadership in cardiology and cardiovascular care, which remains a core strength today. We've expanded into other areas throughout our system as well to integrate innovations in surgery, medicine, oncology and imaging. Notably, we are also deeply committed to education and knowledge dissemination. Our advanced education platforms include our widely followed DeBakey CV Education YouTube channel, which reaches and educates clinicians and patients around the world.

Q: What Attracts Physicians and Researchers to Work at Houston Methodist?

Houston Methodist is an academic health system that takes discovery at our main campus and conveys it across all our network hospitals, prioritizing an exceptional patient experience. We are one system — one Houston Methodist — guided by our faith-based foundation and I CARE values of integrity, compassion, accountability, respect and excellence. We’re further set apart by our innovation, from technology-enabled hospitals and clinics to wearable biosensors, virtual nursing and data-driven insight. In addition, we train the next generation of physicians to possess the same ethos — practicing patient-first, unparalleled care.
Houston Methodist is also a genuinely energizing and inspiring place to work. Our shared purpose and passion are the secret sauce. You can’t bottle it, but it's real, and it matters.
Hear more from Dr. Chang below.